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KMID : 0378019910340110116
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New Medical Journal
1991 Volume.34 No. 11 p.116 ~ p.122
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Ocular Hypotensive Effect of Betagan^(®) in Ocular Hypertension and Open Angle Glaucoma
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한태원/Hahn, Tae Won
김만수/안명덕/김재호/Kim, Man Soo/Ahn, Myong Duk/Kim, Jae Ho
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Abstract
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The effects on topically applied Betagan® (0.5% levobunolol hydrochloride) a non selective beta 1,2 blocker on intraocular-pressure(IOP). pulse rate, blood pressure, pupil diameter and its adverse reactions were studied in twenty healthy volunteers. one ocular hypertension and nineteen primary open glaucoma patients.
During the 24 hours after instillation of Betagan® to normal and glaucoma patients two times a day, the change of intraocular pressure, pulse rate, blood pressure and pupillary diameter were measured. The same method was repeated in primary- open angle glaucoma patients that were followed up for 2 months after using Betagan® were also evaluated at 1.2.4 and 8 weeks.
The results were follows ,
1. The early IOP reduction in healthy volunteers and glaucoma patients appeared at 1 hour after using Betagan® and maximal reduction of IOP was noted at 4hours after instillation of Betagan®.
2. Intraocular pressure reduction of glaucoma patients during the 2months after instillation of Betagan® was 20.1% to 2r".2% of pre-instillation level. It has statistical significance and maintained through out the study.
3. The blood pressure and heart rates were slightly decreased with Betagan but its amount was not significant clinically.
4. The irritation and conjunctival injection at instillation of Betagan® were the most frequently encounted local adverse reactions.
From these results. Betagan(0.5% levobunolol hydrochloride) is considered to be clinically effective beta blocker in glaucoma patients.
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